optimal

Optimal Vector and Delivery Route Selection

Because of the resources available at Dr. Wilson’s Gene Therapy Program, we are able to focus on unique aspects and therapy goals for a given indication and screen a variety of AAVs in non-human primates to choose the optimal capsid and route of delivery to best meet the clinical needs of the patient.

Improved tissue / cell-type targeting translating to reduced toxicity

Higher efficiency of transduction, allowing for improved efficiency

Lower rate of pre-existing neutralizing antibodies

Select Optimal AAV

Indication
Utilize best delivery route
Delivery
Toxicity
AAV Abs Impact
Procedure
Intraparenchymal Intraparenchymal
Limited
High
IV IV
Limited/ Very High Doses
Systemic
Limits efficacy
Lumbar Lumbar
Limited
Low
No Impact
Routine
ICV ICV
Diffuse
High
No Impact
Interventional Radiologist
ICM ICM
Diffuse
Low
No Impact
Interventional Radiologist