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Vector Selection and Delivery

optimal

Optimal Vector and Delivery Route Selection

Because of the resources available at Dr. Wilson’s Gene Therapy Program, we are able to focus on unique aspects and therapy goals for a given indication and screen a variety of AAVs in non-human primates to choose the optimal capsid and route of delivery to best meet the clinical needs of the patient.

Improved tissue / cell-type targeting translating to reduced toxicity

Higher efficiency of transduction, allowing for improved efficiency

Lower rate of pre-existing neutralizing antibodies

Select Optimal AAV

Indication
Utilize best delivery route
Delivery
Toxicity
AAV Abs Impact
Procedure
Intraparenchymal Intraparenchymal
Limited
High
IV IV
Limited/ Very High Doses
Systemic
Limits efficacy
Lumbar Lumbar
Limited
Low
No Impact
Routine
ICV ICV
Diffuse
High
No Impact
Interventional Radiologist
ICM ICM
Diffuse
Low
No Impact
Interventional Radiologist